Administrative Information

المعلومات الادارية

عنوان المشروع- Project Title

بلغة اجنبية:

Effect and mode of action of TNF-α on the activity and protein expression

of the Na+-K+ATPase in cardiac myocytes.

باللغة العربية:

غير متوفر

الباحث الرئيسي Principal Investigator -

الاسم Name	المؤسسة Institution	الوظيفية Post	العنوان Address	العنوان الالكتروني e-mail	رقم الهاتف Telephone
Sawsan Kreydiyyeh	American University of Beirut	Professor	Bliss str., Beirut, Lebanon	sawkreyd@aub.edu.lb	01/350000/3906

الباحثون المشاركون Co-Workers -

None

المدة التعاقدية للمشروع Duration -: (1 year)

Scientific Information

المعلومات العلميّة

الهدف- Objectives

TNF-α was shown to contribute to myocardial contractile dysfunction and cardiomyocyte

death. Since heart diseases are usually associated with alterations in the activity of some ion transporters, this work was undertaken to investigate the effect of NF-α on the Na+-K+ pump and the Na+K+2Cl- cotransporter of the heart and elucidate its mechanism of action.

ألانجازات المحققة Achievements -

The work demonstrated that TNF-α alters the activity of the Na+-K+ATPase

by inducing PGE2 release through different pathways involving NF-κB and AP-1.

PGE2 then, depending on its concentration, may activate different types of EP receptors and different signaling pathways leading to different effects on the activity of the Na+-K+ATPase

آفاق البحث Perspectives -

With the widespread incidence of congestive heart failure, it becomes imperative to look for still unknown causes and possible treatments.

This study uncovers new active molecules that help in the incidence of heart failure .Understanding the role of TNF-α in heart diseases and unraveling its signal transduction pathway would help in finding new drugs that could block or exacerbate the effect of the cytokine by interfering in any of the steps involved in its signaling mechanism. Anti-cytokine therapy studies have already yielded promising results.

المنشورات والمساهمات في المؤتمرات- Publications & Communications

Skayian, Yester, Kreydiyyeh, Sawsan Ibrahim, Tumor necrosis

factor alpha alters Na+ − K+ ATPase activity in rat cardiac myocytes: involvement of

NF-κB, AP-1 and PGE2, Life Sciences 80(2):173-80. (2006).

موجز باللغة العربية عن نتائج البحث Abstract in Arabic

أظهر هذا البحث أن ال TNF-α ، بتنشيطه للNF-KB و الِAP1 ، يؤدي الى افراز ال PGE2 الذي ينشط،، حسب تركيزه، مسارات مختلفة تؤثر على نشاط مضخة الصوديوم و البوتاسيوم بطريقة متباينة.